2-(2-Dimethylaminoethoxy)-4-nitroanisole → 3-(2-(Dimethylamino)ethoxy)-4-methoxyaniline

HRID 399268ノート

反応式

HRID 399268 の反応式
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:7]=1[O:15][CH3:16]>C(O)C.[Pd]>[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([CH:9]=[CH:8][C:7]=1[O:15][CH3:16])[NH2:12]

参加物

4

反応物 1

HCID 107764242-(2-Dimethylaminoethoxy)-4-nitroanisole

生成物 1

HCID 105603983-(2-(Dimethylamino)ethoxy)-4-methoxyaniline収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-(2-dimethylaminoethoxy)-4-nitroanisole (D10, 11.8 g, 0.049 mole) in ethanol (200 ml) was hydrogenated over 10% Pd-C (1 g) at atmospheric temperature and pressure. The catalyst was filtered off through kieselguhr and the filtrate concentrated in vacuo to afford the title compound as a beige solid (10.3 g, 100%).

後処理

  1. filtrationThe catalyst was filtered off through kieselguhr
  2. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-9fa44c1a12b4477088e773850b35097d
出典データセット
uspto-grants-1998_10
特許番号
US05817833

反応ノート

読み込み中…