Sodium Hydroxide → 1-Bromo-3-chloro-3-fluoro-7-oxabicyclo[4.1.0]heptane
反応式
Cl[C:2]12[O:8][CH:7]1[CH2:6][CH2:5][C:4]([Cl:10])([F:9])[CH2:3]2.[Br:11]C1(Cl)CCCC(Cl)(F)C1O.[OH-].[Na+]>O>[Br:11][C:2]12[O:8][CH:7]1[CH2:6][CH2:5][C:4]([Cl:10])([F:9])[CH2:3]2参加物
5
実験手順
The same procedure was followed as for the production of 2e in Example 17: it was performed with 0.20 g (0.75 mmol) of alcohol 1i, 3 cm3 of water and 0.12 g (3 mmol) of sodium hydroxide. Reaction time: 1 h 15 min; ether extraction (4×7 cm3). After treatment, 0.15 g of epoxide 2g were obtained (macrobore GC purity>97.5%), having a yield of 80%.
後処理
- customReaction time
- custom1 h 15 min
- extractionether extraction (4×7 cm3)
出典と根拠
- ORDレコード
- ord-c774fd78aad1421d9ad02b0f0b1d2519
- 出典データセット
- uspto-grants-1998_10
- 特許番号
- US05817890
反応ノート
読み込み中…