Benzenesulfonyl chloride → 2'-Chloro-4'-nitrobenzenesulfonanilide

HRID 399477ノート

反応式

HRID 399477 の反応式
[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:12]1([S:18](Cl)(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][S:18]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:20])=[O:19]

参加物

4

反応物 2

HCID 7369Benzenesulfonyl chlorideHCID 84922-Chloro-4-nitroaniline

生成物 1

HCID 2318362'-Chloro-4'-nitrobenzenesulfonanilide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2-chloro-4-nitroaniline (4.33 g), benzenesulphonyl chloride (3.25 ml) and pyridine (2.5 ml) was stirred and heated to 100° C. for 18 hours. The mixture was cooled to ambient temperature and partitioned between methylene chloride and 2M aqueous hydrochloric acid. The organic phase was washed with water, dried and evaporated. The residue was recrystallised from ethyl acetate to give N-(2-chloro-4-nitrophenyl)benzenesulphonamide (6.07 g), m.p. 155°-157° C.

後処理

  1. temperatureThe mixture was cooled to ambient temperature
  2. custompartitioned between methylene chloride and 2M aqueous hydrochloric acid
  3. washThe organic phase was washed with water
  4. customdried
  5. customevaporated
  6. customThe residue was recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-c466971758344711aafc5413143c01f3
出典データセット
uspto-grants-1998_10
特許番号
US05821246

反応ノート

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