Jineol → 3,8-Dimethoxy quinoline

HRID 399742

反応式

HRID 399742 の反応式
[CH:1]1[CH:10]=[C:9]([OH:11])[C:8]2[N:7]=CC(O)=[CH:4][C:3]=2[CH:2]=1.[N+](=[CH2:15])=[N-].C[CH2:17][O:18][CH2:19][CH3:20]>C(O)C>[CH3:17][O:18][C:19]1[CH:20]=[N:7][C:8]2[C:3]([CH:4]=1)=[CH:2][CH:1]=[CH:10][C:9]=2[O:11][CH3:15]

参加物

4

反応物 2

HCID 177338JineolHCID 21186548Diazomethane diethylether

生成物 1

HCID 105837983,8-Dimethoxy quinoline収率 80%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Jineol of 4.5 mg was dissolved in 2 ml of ethanol, and diazomethane ether solution was slowly dropped to the solution. After the excess of diazomethane and solvent was removed by purging with nitrogen gas, the solution was purified by silicagel chromatography to give 4.2 mg of 3,8-dimethoxy quinoline with 80% yield.

後処理

  1. customAfter the excess of diazomethane and solvent was removed
  2. customby purging with nitrogen gas
  3. customthe solution was purified by silicagel chromatography

出典と根拠

ORDレコード
ord-a3d35d944aca43608a8e9c356519b602
出典データセット
uspto-grants-1998_10
特許番号
US05824689

関連ノート

読み込み中…