Methyl iodide → 3,8-Dimethoxy quinoline
反応式
[OH:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[O:12][CH3:13].[OH-].[K+].I[CH3:17]>C(O)C>[CH3:17][O:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][C:6]=2[O:12][CH3:13]参加物
5
実験手順
175 mg of 3-hydroxy-8-methoxy quinoline [compound (V)] prepared in example 6 and 66 mg of potassium hydroxide were added to 3 ml of ethanol, and the solution was agitated for 30 minutes. To the solution was added 284 mg of iodomethane, and the solution was agitated for 24 hours. The solvent was removed, and the solution was extracted with dichloromethane. The dichloromethane layer was washed with water and aqueous sodium hydroxide, and dried with anhydrous magnesium sulfate. The dichloromethane was removed by vacuum distillation to give 165 mg of 3,8-dimethoxy quinoline.
後処理
- stirringthe solution was agitated for 24 hours
- customThe solvent was removed
- extractionthe solution was extracted with dichloromethane
- washThe dichloromethane layer was washed with water and aqueous sodium hydroxide
- dry with materialdried with anhydrous magnesium sulfate
- customThe dichloromethane was removed by vacuum distillation
出典と根拠
- ORDレコード
- ord-aaf958ebc6be4ebdac4f38df1b6371fc
- 出典データセット
- uspto-grants-1998_10
- 特許番号
- US05824689
反応ノート
読み込み中…