3-Bromophenylhydrazine hydrochloride → HCID 67613181、化合物

HRID 399772

反応式

HRID 399772 の反応式
Cl.[Br:2][C:3]1[CH:4]=[C:5]([NH:9][NH2:10])[CH:6]=[CH:7][CH:8]=1.[O:11]1[CH:15]=[CH:14][CH2:13][CH2:12]1>C1COCC1>[Br:2][C:3]1[CH:4]=[C:5]([NH:9][N:10]=[CH:15][CH2:14][CH2:13][CH2:12][OH:11])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 337573-Bromophenylhydrazine hydrochlorideHCID 709342,3-Dihydrofuran

生成物 1

HCID 67613181HCID 67613181、化合物収率 99.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under anhydrous conditions a solution of 3-bromophenylhydrazine hydrochloride (22.5 g, 100 mmol) and 2,3-dihydrofuran (7.55 ml, 100 mmol) in 200 ml of dry THF was stirred at ambient temperature for 3 h. The reaction mixture was partitioned between EtOAc and H2O. The organic phase was washed with H2O and brine. After drying (Na2 SO4), the solvent was evaporated to give 25.6 g of the product as a brown oil. The product was of suitable purity for use in the next step.

後処理

  1. customThe reaction mixture was partitioned between EtOAc and H2O
  2. washThe organic phase was washed with H2O and brine
  3. customAfter drying (Na2 SO4)
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-71f44accceb34da08c5f8b2e174c5c94
出典データセット
uspto-grants-1998_10
特許番号
US05824699

関連ノート

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