Hydrochloric Acid → 3-(2-Benzyloxycarbonylpyrrol-1-yl)benzoic acid

HRID 399820ノート

反応式

HRID 399820 の反応式
[OH-].[Na+].[CH2:3]([O:10][C:11]([C:13]1[N:14]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23]C)=[O:22])[CH:15]=[CH:16][CH:17]=1)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O1CCOCC1.Cl>O.C(OCC)(=O)C>[CH2:3]([O:10][C:11]([C:13]1[N:14]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([OH:23])=[O:22])[CH:15]=[CH:16][CH:17]=1)=[O:12])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 18945465Methyl 3-(2-benzyloxycarbonylpyrrol-1-yl)benzoate

生成物 1

HCID 189453413-(2-Benzyloxycarbonylpyrrol-1-yl)benzoic acid収率 50.1%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

1N-Sodium hydroxide solution (1.5 ml) was added to a mixture of methyl 3-(2-benzyloxycarbonylpyrrol-1-yl)benzoate (0.5 g) and dioxane (20 ml), and the mixture was stirred for 3 days at ambient temperature. The reaction mixture was poured into the mixture of ethyl acetate and water and the separated aqueous layer was adjusted to pH 1 with 6N-hydrochloric acid. The mixture was extracted with ethyl acetate and extract was washed with brine and dried over magnesium sulfate. The solvent was removed by concentration and the residue was triturated with n-hexane to give 3-(2-benzyloxycarbonylpyrrol-1-yl)benzoic acid (0.24 g).

後処理

  1. extractionThe mixture was extracted with ethyl acetate
  2. extractionextract
  3. washwas washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was removed by concentration
  6. customthe residue was triturated with n-hexane

出典と根拠

ORDレコード
ord-e86ac1fc5fd84afd8327dc1ea33c1f1d
出典データセット
uspto-grants-1998_10
特許番号
US05824691

反応ノート

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