Hydrogen chloride-ethyl acetate → HCID 67539282、化合物

HRID 40020ノート

反応式

HRID 40020 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:35])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]([O:33][CH3:34])[C:26]4[O:27][CH2:28][CH2:29][O:30][C:25]=4[CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:36].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:36].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:35])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]([O:33][CH3:34])[C:26]4[O:27][CH2:28][CH2:29][O:30][C:25]=4[CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983727-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

生成物 1

HCID 67539282HCID 67539282、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To 10 mL of a chloroform solution containing 478 mg of 7-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate and 5 mL of chloroform were added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 429 mg of 7-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a dark brown powder.

後処理

  1. additionwere added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

出典と根拠

ORDレコード
ord-1292a5c68c664ecc89730649bc39f57d
出典データセット
uspto-grants-2013_09
特許番号
US08524738B2

反応ノート

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