4-Aminobutanal → HCID 18944389、化合物

A! A solution of 4-aminobutyraldehyde diethylacetale (90 ml, 0.5 mole) and butyl bromide (121 ml, 1.1 mole) in ethanol (1.000 ml) was added with a 1N solution of sodium hydroxide (1.130 ml). The reaction mixture was refluxed for 8 hours. The reaction solvent was evaporated off and the aqueous solution was extracted with diethyl ether. The organic phases were combined and anhydrified over sodium sulfate, then evaporated under vacuum. The resulting crude was purified by fractionated distillation to yield 54 g of 4-dibutylaminobutyraldehyde diethylacetale (yield: 39%). B.p.: 95°-06° C. (0,05 mmHg).

1. temperatureThe reaction mixture was refluxed for 8 hours
2. customThe reaction solvent was evaporated off
3. extractionthe aqueous solution was extracted with diethyl ether
4. customevaporated under vacuum
5. distillationThe resulting crude was purified by fractionated distillation

ORDレコード

ord-ff738e2080e34a5382cf0f8aad79fbd6

出典データセット

uspto-grants-1998_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05827881