Tert-Butylamine → N-(1,1-Dimethylethyl)benzenesulfonamide

HRID 400301

反応式

HRID 400301 の反応式
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[C:6]1([S:12](Cl)(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1>[C:1]([NH:5][S:12]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:14])=[O:13])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 6385Tert-ButylamineHCID 7369Benzenesulfonyl chloride

生成物 1

HCID 314059N-(1,1-Dimethylethyl)benzenesulfonamide収率 95.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a cooled (0° C.) solution of tert-butylamine (42.9 mL, 410.6 mmol) in THF (840 mL) was added dropwise benzenesulfonyl chloride (26.2 mL, 205 mmol) and the reaction mixture was stirred at room temperature under an argon atmosphere for 6 h. The mixture was then filtered and the collected solid washed with THF. The filtrate was concentrated, redissolved in CH2Cl2 and washed with 0.1N HCl and H2O. The organic solution was dried and concentrated to afford the desired product (41.8 g, 95%).

後処理

  1. filtrationThe mixture was then filtered
  2. washthe collected solid washed with THF
  3. concentrationThe filtrate was concentrated
  4. dissolutionredissolved in CH2Cl2
  5. washwashed with 0.1N HCl and H2O
  6. customThe organic solution was dried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-1b6044d52b904ce0a18f29ce5dce3756
出典データセット
uspto-grants-1998_10
特許番号
US05827863

関連ノート

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