Ether hydrochloride → 1-Benzyl-2-isopropyl-6-methoxy-1H-indole

HRID 40031ノート

反応式

HRID 40031 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[CH:10]=[C:9]1[C:19](O)([CH3:21])[CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.CCOCC>CCOC(C)=O.CCO.[Pd]>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[CH:10]=[C:9]1[CH:19]([CH3:21])[CH3:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 2

HCID 10953452Ether hydrochlorideHCID 597622752-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol2 回

生成物 1

HCID 597624051-Benzyl-2-isopropyl-6-methoxy-1H-indole

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol (Compound 3, 1.05 g, 3.57 mmol) in EtOAc (35 ml) and EtOH (15 ml) was added 10% Pd—C (190 mg, 0.18 mmol) and HCl-Et2O (1.0 M, 1.25 ml, 1.25 mmol). The mixture was stirred under hydrogen gas (atmospheric pressure) for 1 h and was filtered. To the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml), followed by Na2SO4 and MgSO4. This was then filtered and concentrated in vacuo to yield the crude title compound as a yellow solid.

後処理

  1. filtrationwas filtered
  2. additionTo the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml)
  3. filtrationThis was then filtered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8ecb303fb22d4ec4a259e5a2f652ee4c
出典データセット
uspto-grants-2013_09
特許番号
US08524917B2

反応ノート

読み込み中…