Hydrochloric Acid → 4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine hydrochloride
反応式
C([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:16][CH:17]=[N:18][C:11]=2[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H].[ClH:27]>C(O)C.[Pd]>[ClH:27].[C:19]1([C:15]2[C:12]3[CH2:13][CH2:14][NH:8][CH2:9][CH2:10][C:11]=3[N:18]=[CH:17][N:16]=2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
Palladium charcoal was added to 17 g 7-benzyl-4-phenyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine in 250 mL ethanol and 54 mL 1 mol/L HCl solution. The reaction was stirred at 80° C. and 5 bar hydrogen. The mixture was filtered and evaporated to give 13.15 g of the desired product.
後処理
- filtrationThe mixture was filtered
- customevaporated
出典と根拠
- ORDレコード
- ord-350a111e8175491ba4901aeda96ba99c
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08741892B2
反応ノート
読み込み中…