Triethylammonium hydroxide → HCID 86686051、化合物

HRID 400453ノート

反応式

HRID 400453 の反応式
[OH-].C([NH+](CC)CC)C.[C:9]([NH:12][CH:13]1[C:17](=[O:18])[CH2:16][N:15]([C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])[CH2:14]1)(=O)[CH3:10]>C1COCC1>[CH2:22]([O:21][C:19]([N:15]1[CH2:16][C:17]2[O:18][C:9]([CH3:10])=[N:12][C:13]=2[CH2:14]1)=[O:20])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

参加物

4

反応物 2

HCID 21903323Triethylammonium hydroxideHCID 86686050Benzyl 3-acetamido-4-oxopyrrolidine-1-carboxylate

生成物 1

HCID 86686051HCID 86686051、化合物収率 31.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
65 °C

実験手順

8.5 g methoxycarbonylsulfamoyl)triethylammoniumhydroxid was added to 4.7 g benzyl 3-acetamido-4-oxopyrrolidine-1-carboxylate in 180 mL THF. The reaction was stirred 1 h at 65° C. and evaporated. The residue was purified on silica gel (hexane/ethyl acetate:1/1) to give 1.4 g of the desired product.

後処理

  1. customevaporated
  2. customThe residue was purified on silica gel (hexane/ethyl acetate:1/1)

出典と根拠

ORDレコード
ord-560ac167e85d483599e1a10467826ce3
出典データセット
uspto-grants-2014_06
特許番号
US08741892B2

反応ノート

読み込み中…