Water → HCID 178497263、化合物

HRID 400485

反応式

HRID 400485 の反応式
C(O)(=O)C.[NH2:5][NH2:6].[CH3:7][O:8][C:9](=[O:21])[C:10](=O)[CH2:11][C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.O>C(O)(=O)C>[CH3:7][O:8][C:9]([C:10]1[CH:11]=[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:6][N:5]=1)=[O:21]

参加物

5

反応物 3

HCID 962WaterHCID 165591Hydrazine, acetate (1:1)HCID 308117Methyl 2,4-dioxo-4-phenylbutanoate

生成物 1

HCID 178497263HCID 178497263、化合物収率 66.3%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

983 mg hydrazine acetate was added to 2 g 2,4-Dioxo-4-phenyl-butyric acid methyl ester in 10 mL concentrated acetic acid. The mixture was stirred over night at RT. Then water was added. The precipitate was filtered, stirred with diisopropylether and again filtered to give 1.3 g desired product. Rt: 1.39 min (method O), (M+H)+: 203

後処理

  1. filtrationThe precipitate was filtered
  2. stirringstirred with diisopropylether
  3. filtrationagain filtered

出典と根拠

ORDレコード
ord-8ffbecc03032464c90cc429146c8e351
出典データセット
uspto-grants-2014_06
特許番号
US08741892B2

関連ノート

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