4-Toluenesulfonyl chloride → Tetrahydrofuran-3-yl 4-methylbenzenesulfonate
反応式
[O:1]1[CH2:5][CH2:4][CH:3]([OH:6])[CH2:2]1.[CH3:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1>N1C=CC=CC=1>[O:1]1[CH2:5][CH2:4][CH:3]([O:6][S:14]([C:11]2[CH:12]=[CH:13][C:8]([CH3:7])=[CH:9][CH:10]=2)(=[O:16])=[O:15])[CH2:2]1参加物
4
実験手順
To a solution of tetrahydrofuran-3-ol (500 mg, 5.67 mmol) in pyridine (10 ml) at 0° C. was added 4-methylbenzene-1-sulfonyl chloride (1.08 g, 5.67 mmol). The reaction was stirred at room temperature overnight. The reaction was quenched with water, extracted with ethyl acetate. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated in vacuo to yield crude oil (1.2 g).
後処理
- customThe reaction was quenched with water
- extractionextracted with ethyl acetate
- washThe organic layer was washed with water, brine
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-3cbe48ced7fd4ce0adb13c99eb89e824
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524917B2
反応ノート
読み込み中…