4-Hydroxy-3-methylbenzonitrile → HCID 67141374、化合物

HRID 400593ノート

反応式

HRID 400593 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH3:10].F[B-](F)(F)F.[O:16]=[N+:17]=[O:18]>C(#N)C.O>[OH:1][C:2]1[C:9]([N+:17]([O-:18])=[O:16])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH3:10]

参加物

5

反応物 2

HCID 109645604-Hydroxy-3-methylbenzonitrileHCID 11073463Nitronium tetrafluoroborate

生成物 1

HCID 67141374HCID 67141374、化合物収率 94%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒

実験手順

A stirred solution of 4-hydroxy-3-methylbenzonitrile (3.1 g, 23.3 mmol) in 60 mL of anhydrous acetonitrile was cooled to −30° C. and treated with nitronium tetrafluoroborate (3.4 g, 25.6 mmol) in portions. After 60 minutes, the reaction mixture was diluted with 100 mL of water. The resulting light yellow precipitate was filtered, washed with water, and dried to give 3.9 g of 4-hydroxy-3-methyl-5-nitrobenzonitrile (94% yield).

後処理

  1. filtrationThe resulting light yellow precipitate was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-9bd1239af7614a7b8aafa67a12e09874
出典データセット
uspto-grants-2014_06
特許番号
US08741897B2

反応ノート

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