Hydrochloric Acid → 4-[(2R)-2-methylpiperidin-1-yl]-3-(trifluoromethyl)benzoic acid

温度

100 °C

4-[(2R)-2-methylpiperidin-1-yl]-3-(trifluoromethyl)benzonitrile (1.40 g; 5.22 mmol; 1 eq.) was dissolved in MeOH (7 mL) to which was added NaOH (5 N solution in water, 7 mL). The reaction mixture was heated to 100° C. for 7 hours. The reaction mixture was acidified to pH 2 with 5N HCl solution in water. The resulting precipitate was filtered and washed with water to give a light brown solid. It was recrystallized from Et2O/cHex to give a beige solid.

1. filtrationThe resulting precipitate was filtered
2. washwashed with water
3. customto give a light brown solid
4. customIt was recrystallized from Et2O/cHex
5. customto give a beige solid

ORDレコード

ord-80be446b6e6e46c6ba33e3de85df24f4

出典データセット

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08741923B2