Ethylene Glycol → 3-(2-Hydroxyethyl)indolin-2-one

HRID 401371ノート

反応式

HRID 401371 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH2:11](O)[CH2:12][OH:13]>[Ni]>[OH:13][CH2:12][CH2:11][CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10]

参加物

4

反応物 2

HCID 174Ethylene GlycolHCID 321710Oxindole

生成物 1

HCID 108992203-(2-Hydroxyethyl)indolin-2-one収率 70%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

A stifling mixture of oxindole (5.7 g, 43 mmol) and Raney nickel (10 g) in ethane-1,2-diol (100 mL) was heated in an autoclave. After the reaction was complete, the mixture was filtered and the excess of diol was removed under vacuum. The residual oil was triturated with hexane to give 3-(2-hydroxy-ethyl)-1,3-dihydro-indol-2-one as a colorless crystalline solid (4.6 g, 70%).

後処理

  1. temperaturewas heated in an autoclave
  2. filtrationthe mixture was filtered
  3. customthe excess of diol was removed under vacuum
  4. customThe residual oil was triturated with hexane

出典と根拠

ORDレコード
ord-923023eac3304e00814ee021f7b24ab6
出典データセット
uspto-grants-2014_06
特許番号
US08741925B2

反応ノート

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