化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → Trifluoroacetylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Tert-butyl 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylate | HCID 20294522 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Trifluoroacetylpiperazine | HCID 7172020 | — |
反応手順
To a solution of compound 1c (15.15 g, 53.69 mmol) in CH2Cl2 (60 mL) was added trifluoroacetic acid (18 mL) at room temperature. The mixture was stirred at room temperature for 18 h. The solvent was removed by evaporation. Ether (100 mL) was added to the residue. The white solid was collected by filtration, washed with ether, and dried under vacuum. The crude compound 1d was used in the next reaction without further purification. MS m/z (M+H+) 183.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741887B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-13a94fe105ab43799c4b132dee85e047 |
| 出典メモ | uspto-grants-2014_06 |