1-(4-Trifluoromethylphenyl)Ethylamine → 4-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]-N-[1-[4-(trifluoromethyl)phenyl]ethyl]benzamide

HRID 401734

反応式

HRID 401734 の反応式
[S:1]1[C:5]([NH:6][S:7]([C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=2)(=[O:9])=[O:8])=[N:4][CH:3]=[N:2]1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:26]=[CH:25][C:24]([CH:27]([NH2:29])[CH3:28])=[CH:23][CH:22]=1>>[S:1]1[C:5]([NH:6][S:7]([C:10]2[CH:11]=[CH:12][C:13]([C:14]([NH:29][CH:27]([C:24]3[CH:23]=[CH:22][C:21]([C:20]([F:19])([F:30])[F:31])=[CH:26][CH:25]=3)[CH3:28])=[O:16])=[CH:17][CH:18]=2)(=[O:8])=[O:9])=[N:4][CH:3]=[N:2]1

参加物

3

反応物 2

HCID 27824491-(4-Trifluoromethylphenyl)EthylamineHCID 577322144-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]benzoic acid

生成物 1

HCID 577320034-[(1,2,4-Thiadiazol-5-ylamino)sulfonyl]-N-[1-[4-(trifluoromethyl)phenyl]ethyl]benzamide

実験手順

The title compound was prepared from 4-[(1,2,4-thiadiazol-5-ylamino)sulfonyl]benzoic acid (Preparation 29) and 1-[4-(trifluoromethyl)phenyl]ethanamine following the procedure described in Example 309. The reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM and the crude product purified by preparative HPLC.

後処理

  1. extractionThe reaction mixture was extracted from saturated sodium hydrogen carbonate into DCM
  2. customthe crude product purified by preparative HPLC

出典と根拠

ORDレコード
ord-4afe0ed5471e4f02bfc3311d06f68277
出典データセット
uspto-grants-2014_06
特許番号
US08741934B2

関連ノート

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