Lithium Hydroxide → 2-Cyclohexyl-1,3-thiazole-4-carboxylic acid

HRID 402182ノート

反応式

HRID 402182 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])C.[Li+].[OH-]>O>[CH:11]1([C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 57956421Ethyl 2-cyclohexylthiazole-4-carboxylate

生成物 1

HCID 234049342-Cyclohexyl-1,3-thiazole-4-carboxylic acid収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 2-cyclohexylthiazole-4-carboxylic acid ethyl ester (116, 6.8 g, 28.5 mmol) in water was added 1M LiOH (50 mL). The solution was kept at room temperature and monitored by LC-MS. When the hydrolysis was completed the reaction mixture was neutralized with myriatic acid and extracted with ethyl acetate and diethyl ether. The organic phase was dried (Na2SO4), filtered and concentrated under reduced pressure to give 5.0 g (83%) of the title compound 117: m/z=212 (M+H)+.

後処理

  1. customwas kept at room temperature
  2. extractionextracted with ethyl acetate and diethyl ether
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-98ffb5f3389e43e1bc4eec0dab76d9f5
出典データセット
uspto-grants-2014_06
特許番号
US08741926B2

反応ノート

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