Quinoline → 2-Amino-4-hydroxy-3-methylbenzonitrile

HRID 402200ノート

反応式

HRID 402200 の反応式
[CH2:1]([N:8]1C(=O)C2=CC=CC=C2C1=O)CCCCC=C.[OH-:19].[Na+].[N:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=CC=1>>[NH2:21][C:30]1[C:25]([CH3:24])=[C:26]([OH:19])[CH:27]=[CH:28][C:29]=1[C:1]#[N:8]

参加物

4

反応物 3

HCID 7047QuinolineHCID 14798Sodium HydroxideHCID 53236045N-(hept-6-enyl)phthalimide

生成物 1

HCID 134647162-Amino-4-hydroxy-3-methylbenzonitrile収率 82%

反応条件

温度
170 °C

実験手順

A mixture of compound 75 (19 g, 0.1 mol) in quinoline (50 mL) was heated to 170° C. for 2 h (until effervescence ceased). The reaction mixture was cooled to RT and aqueous NaOH solution was added (1M, 500 mL) followed by pet. ether (500 mL). The reaction mixture was stirred for 15 min and the aqueous layer was separated. The aqueous layer was further washed with pet. ether (2×300 mL) to remove quinoline completely. The aqueous layer was acidified with 1.5N HCl to pH=5, the solid was filtered off and dried under vacuum. The obtained solid was further washed with 5% ethyl acetate in pet. ether to give pure title compound (12 g, 82%).

後処理

  1. temperatureThe reaction mixture was cooled to RT
  2. customthe aqueous layer was separated
  3. washThe aqueous layer was further washed with pet. ether (2×300 mL)
  4. customto remove quinoline completely
  5. filtrationthe solid was filtered off
  6. customdried under vacuum
  7. washThe obtained solid was further washed with 5% ethyl acetate in pet. ether

出典と根拠

ORDレコード
ord-aa4ce2d37feb495aa6594d3515388459
出典データセット
uspto-grants-2014_06
特許番号
US08741926B2

反応ノート

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