Ammonium Chloride → 2-Methyl-4-(2-pyrimidinylmethoxy)aniline

HRID 402692ノート

反応式

HRID 402692 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[N+:16]([O-])=O)[O:5][CH2:6][C:7]1[N:12]=[CH:11][CH:10]=[CH:9][N:8]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[CH3:1][C:2]1[CH:3]=[C:4]([O:5][CH2:6][C:7]2[N:8]=[CH:9][CH:10]=[CH:11][N:12]=2)[CH:13]=[CH:14][C:15]=1[NH2:16]

参加物

6

反応物 2

HCID 25517Ammonium ChlorideHCID 867083912-[(3-Methyl-4-nitrophenoxy)methyl]pyrimidine

生成物 1

HCID 626995032-Methyl-4-(2-pyrimidinylmethoxy)aniline収率 99.6%

試薬・触媒・溶媒 3

HCID 23925Iron触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 2-[(3-methyl-4-nitrophenoxy)methyl]pyrimidine (0.18 g, 0.7 mmol) in ethanol (4.0 mL) and water (1.0 mL), iron (0.40 g, 7.2 mmol) and ammonium chloride (0.020 g, 0.37 mmol) were added. The mixture was refluxed for 1.5 h. Cooled to ambient temperature, the reaction mixture was filtered over Celite to remove unneeded materials and the filtrate was concentrated to afford 2-methyl-4-(2-pyrimidinylmethoxy)aniline (0.15 g, crude material) as solid.

後処理

  1. temperatureThe mixture was refluxed for 1.5 h
  2. filtrationthe reaction mixture was filtered over Celite
  3. customto remove unneeded materials
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-40efd4005d31432296f872f2bb583007
出典データセット
uspto-grants-2014_06
特許番号
US08742113B2

反応ノート

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