N,N-diethylpiperidin-4-amine dihydrochloride → N,N-diethylpiperidin-4-amine
反応式
Cl.Cl.[CH2:3]([N:5]([CH2:12][CH3:13])[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:4]>O.[OH-].[Na+]>[CH2:12]([N:5]([CH2:3][CH3:4])[CH:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)[CH3:13]参加物
4
実験手順
To a solution of 4-(diethylamino)piperidine dihydrochloride (3.0 g, 0.019 mmol) in water (20 mL), 2M sodium hydroxide solution (5.0 mL) was added at ambient temperature. The mixture was stirred for 30 min. The solvent was removed under reduced pressure, and methanol (10 mL) was added to the crude material, then the residue was removed by filtration. The filtrate was concentrated and dried to afford 4-(diethylamino)piperidine (1.7 g, y. 77%) as solid.
後処理
- customThe solvent was removed under reduced pressure, and methanol (10 mL)
- additionwas added to the crude material
- customthe residue was removed by filtration
- concentrationThe filtrate was concentrated
- customdried
出典と根拠
- ORDレコード
- ord-e3c7ab6f7b484b4da9c0182a6621a93e
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08742113B2
反応ノート
読み込み中…