Potassium Carbonate → HCID 66765091、化合物

HRID 402756

反応式

HRID 402756 の反応式
C(=O)([O-])[O-].[K+].[K+].Cl.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O=[C:17]([C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:18][C:19](OCC)=[O:20]>CCO>[C:8]1([N:14]2[C:19](=[O:20])[CH2:18][C:17]([C:24]3[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=3[F:32])=[N:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 60962Phenylhydrazine hydrochlorideHCID 2758933Ethyl 2,4,5-trifluorobenzoylacetate

生成物 1

HCID 66765091HCID 66765091、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

Potassium carbonate (153 mg, 1.10 mmol) was added to a stirred mixture of phenyl hydrazine HCl salt (160 mg, 1.10 mmol) and ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate (272 mg, 1.10 mmol) in EtOH (6 mL) and the mixture was heated at 70° C. for 1 hour. The solution was cooled to room temperature and was concentrated to give the title compound, which was taken on to the next step.

後処理

  1. temperatureThe solution was cooled to room temperature
  2. concentrationwas concentrated

出典と根拠

ORDレコード
ord-3b8aeac09dcf44bfbc8b68645c6200f3
出典データセット
uspto-grants-2014_06
特許番号
US08742110B2

関連ノート

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