Acetic Anhydride → 9-Acetyl-3-bromocarbazole

HRID 403149ノート

反応式

HRID 403149 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3.[C:15](OC(=O)C)(=[O:17])[CH3:16]>OS(O)(=O)=O.C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:15](=[O:17])[CH3:16])[C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3

参加物

5

反応物 2

HCID 7918Acetic AnhydrideHCID 2524463-Bromocarbazole

生成物 1

HCID 17148799-Acetyl-3-bromocarbazole収率 52.1%

試薬・触媒・溶媒 2

HCID 1118Sulfuric Acid触媒HCID 6212Chloroform溶媒

実験手順

A solution of 3-bromo-9H-carbazole (10.00 g, 40.6 mmol), acetic anhydride (8.30 g, 81 mmol) together with 2 drops of H2SO4 in chloroform (150 mL) was refluxed overnight. After cooling to room temperature, the solution was washed with water. Upon evaporation of the solvent, the crude product was purified by crystallization from hexane/DCM and hexane/EtOAc to yield 1-(3-bromo-9H-carbazol-9-yl)ethanone (6.1 g, 51% yield) as a light yellow solid.

後処理

  1. washthe solution was washed with water
  2. customUpon evaporation of the solvent
  3. customthe crude product was purified by crystallization from hexane/DCM and hexane/EtOAc

出典と根拠

ORDレコード
ord-448e779b27c0471baaa8051f1674588c
出典データセット
uspto-grants-2014_06
特許番号
US08748012B2

反応ノート

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