Dimethylformamide → 3-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride

HRID 403296ノート

反応式

HRID 403296 の反応式
[F:1][C:2]1[C:3]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7](O)=[O:8].C(Cl)(C([Cl:24])=O)=O.CN(C=O)C>C(Cl)Cl>[F:1][C:2]1[C:3]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:11]=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([Cl:24])=[O:8]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 596258253-Fluoro-5-phenyl-benzo[b]thiophene-2-carboxylic acid

生成物 1

HCID 596257253-Fluoro-5-phenyl-benzo[b]thiophene-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of compound 13d (136.2 mg, 0.5 mmol) in CH2Cl2 (5 mL) at room temperature was added (COCl)2 (0.064 mL, 0.75 mmol), followed by DMF (0.01 mL, 0.125 mmol). The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was then concentrated to give compound 13e as a light pink powder, which was used in the next reaction without further purification.

後処理

  1. concentrationThe reaction mixture was then concentrated

出典と根拠

ORDレコード
ord-a0994920e26b416889a4bff7ba927092
出典データセット
uspto-grants-2014_06
特許番号
US08748417B2

反応ノート

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