Ethyl 2-thiopheneglyoxylate → HCID 67289955、化合物

HRID 403429

反応式

HRID 403429 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[Cl:8].O=[C:12]([C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)[C:13](OCC)=[O:14]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][C:7]=1[Cl:8])[NH:9][C:13](=[O:14])[C:12]([C:18]1[S:19][CH:20]=[CH:21][CH:22]=1)=[N:10]2

参加物

4

反応物 2

HCID 77693Ethyl 2-thiopheneglyoxylateHCID 792974,5-Dichloro-1,2-phenylenediamine

生成物 1

HCID 67289955HCID 67289955、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

A mixture of 4,5-dichlorobenzene-1,2-diamine (1.0 g, 5.65 mmol), ethyl 2-oxo-2-(thiophen-2-yl)acetate (1.056 g, 5.73 mmol) and ethanol (8 ml) was stirred at 70° C. for 11 h, cooled to room temperature, filtered and washed with cold ethanol. The collected pale yellow solid was dried further (1.07 g) and used directly in next step.

後処理

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. washwashed with cold ethanol
  4. customThe collected pale yellow solid was dried further (1.07 g)

出典と根拠

ORDレコード
ord-e2e509857fd348abbb23af2cdb1c66cc
出典データセット
uspto-grants-2014_06
特許番号
US08748374B2

関連ノート

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