反応式
[F:1][C:2]([F:32])([C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][C:24]([O:30][CH3:31])=[CH:23]2)[C:3]([NH:5][NH:6][C:7]1[C:12]([F:13])=[CH:11][C:10]([C:14]2[CH:15]=[N:16][N:17]([CH3:19])[CH:18]=2)=[CH:9][N:8]=1)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.ClC(Cl)C.C(N(C(C)C)CC)(C)C.ClC(Cl)(Cl)C#N>CO>[F:1][C:2]([F:32])([C:3]1[N:8]2[CH:9]=[C:10]([C:14]3[CH:15]=[N:16][N:17]([CH3:19])[CH:18]=3)[CH:11]=[C:12]([F:13])[C:7]2=[N:6][N:5]=1)[C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][C:24]([O:30][CH3:31])=[CH:23]2参加物
反応物 5
生成物 1
試薬・触媒・溶媒 1
実験手順
A sealable microwave vial was charged with 2,2-difluoro-N′-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-(3-methoxyquinolin-6-yl)acetohydrazide (225 mg, 509 μmol) and polymer supported triphenylphosphine (2.3 mmol/g, 221 mg, 509 μmol). The flask was sealed and dichloroethane (4 mL) was added followed by diisopropylethylamine (89 μl, 509 μmol) and 2,2,2-trichloroacetonitrile (127 μl, 1271 μmol). The resulting mixture was irradiated in a microwave (Biotage Initiator) at 150° C. for 40 min. The reaction mixture was filtered and the filter cake was washed with CH2Cl2 (15 mL) and MeOH (10 mL). The filtrate was concentrated in vacuo and the resulting crude residue was purified by MPLC using 100% CH2Cl2 to 98:2 CH2Cl2: MeOH to afford 6-(difluoro(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)methyl)-3-methoxyquinoline (94 mg, 44% yield) as a tan amorphous solid. LRMS (ESI) m/z calcd for C21H16F3N6O (M+H) 425.1. found 425.4.
後処理
- customThe flask was sealed
- customThe resulting mixture was irradiated in a microwave (Biotage Initiator) at 150° C. for 40 min
- filtrationThe reaction mixture was filtered
- washthe filter cake was washed with CH2Cl2 (15 mL) and MeOH (10 mL)
- concentrationThe filtrate was concentrated in vacuo
- customthe resulting crude residue was purified by MPLC
出典と根拠
- ORDレコード
- ord-712ac1ce46ef4d04b530ac6ec62b590d
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524900B2
関連ノート
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