Benzenamine, 3-ethynyl- → 4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride

HRID 403663ノート

反応式

HRID 403663 の反応式
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[Cl:17])(=[O:3])[CH3:2].[C:18]([C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23])#[CH:19]>C(Cl)(Cl)Cl>[ClH:17].[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][N:9]=[C:8]2[NH:23][C:22]1[CH:24]=[CH:25][CH:26]=[C:20]([C:18]#[CH:19])[CH:21]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 104682Benzenamine, 3-ethynyl-HCID 220221604-Chloro-7-methoxyquinazolin-6-yl acetate

生成物 1

HCID 866599184-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl acetate Hydrochloride収率 89.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 4-chloro-7-methoxyquinazolin-6-yl acetate (7.75 g, 0.0307 mol), 3-ethynyl aniline (4 g, 0.0342 mol, 1.11 equiv) and chloroform (120 ml) was refluxed overnight. The reaction mixture was cooled to room temperature and the solution was filtered to give 10.2 g product. MS (ESI) m/z: 334 (M+1).

後処理

  1. temperaturewas refluxed overnight
  2. filtrationthe solution was filtered

出典と根拠

ORDレコード
ord-8f3681ffb6ad484ea8cae4a59c2ee67d
出典データセット
uspto-grants-2014_06
特許番号
US08748453B2

反応ノート

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