4-Chloro-2-phenoxyphenyl isocyanate → (S)-Methyl 2-(6-(5-(3-(4-chloro-2-phenoxyphenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

HRID 403987

反応式

HRID 403987 の反応式
ClC1C=CC=CC=1[NH:8][C:9](=[O:35])[NH:10][C:11]1[CH:12]=[CH:13][C:14]([C:17]2[CH:25]=[C:24]3[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]3=[O:26])=[CH:19][CH:18]=2)=[N:15][CH:16]=1.NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=NC=1.[Cl:61][C:62]1[CH:67]=[CH:66][C:65](N=C=O)=[C:64]([O:71][C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][CH:73]=2)[CH:63]=1>>[Cl:61][C:62]1[CH:67]=[CH:66][C:65]([NH:8][C:9](=[O:35])[NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:25]=[C:24]4[C:20]([CH2:21][N:22]([C@@H:27]([CH:32]([CH3:34])[CH3:33])[C:28]([O:30][CH3:31])=[O:29])[C:23]4=[O:26])=[CH:19][CH:18]=3)=[N:15][CH:16]=2)=[C:64]([O:71][C:72]2[CH:73]=[CH:74][CH:75]=[CH:76][CH:77]=2)[CH:63]=1

参加物

4

反応物 3

HCID 34074334-Chloro-2-phenoxyphenyl isocyanateHCID 131731548(S)-Methyl 2-(6-(5-aminopyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731549(S)-Methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

生成物 1

HCID 53302548(S)-Methyl 2-(6-(5-(3-(4-chloro-2-phenoxyphenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

実験手順

The compound of example 395 was prepared analogous to the compound of example 393 by reaction of the compound of example 392 with 4-chloro-2-phenoxy phenyl isocyanate. The compound of example 395 was used directly for the preparation of compound of example 396 without purification.

出典と根拠

ORDレコード
ord-926b1bc0a62943419c5534de587990fb
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

関連ノート

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