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HRID 403987作成日:2026年10月26日

4-Chloro-2-phenoxyphenyl isocyanate → (S)-Methyl 2-(6-(5-(3-(4-chloro-2-phenoxyphenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoate

https://huagongshe.com/reaction/403987

反応式

関与物質

役割名称HCID仕込み量
反応物4-Chloro-2-phenoxyphenyl isocyanateHCID 3407433—
反応物(S)-Methyl 2-(6-(5-aminopyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731548—
反応物(S)-Methyl 2-(6-(5-(3-(2-chlorophenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 131731549—
生成物(S)-Methyl 2-(6-(5-(3-(4-chloro-2-phenoxyphenyl)ureido)pyridin-2-yl)-1-oxoisoindolin-2-yl)-3-methylbutanoateHCID 53302548—

反応手順

The compound of example 395 was prepared analogous to the compound of example 393 by reaction of the compound of example 392 with 4-chloro-2-phenoxy phenyl isocyanate. The compound of example 395 was used directly for the preparation of compound of example 396 without purification.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08748426B2
出典データセットuspto-grants-2014_06
ORD IDord-926b1bc0a62943419c5534de587990fb
出典メモuspto-grants-2014_06