Methyl 1-aminocyclobutane-1-carboxylate hydrochloride → Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylate

HRID 404065

反応式

HRID 404065 の反応式
CC(C)[C@H:3]([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:17]3[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=3)=[CH:13][CH:14]=2)[C:9]1=[O:26])[C:4]([O:6][CH3:7])=[O:5].Br[CH2:29][C:30]1C=CC(C2C=CC([N+]([O-])=O)=CC=2)=C[C:31]=1C(OC)=O.Cl.NC1(C(OC)=O)CCC1>>[N+:23]([C:20]1[CH:19]=[CH:18][C:17]([C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][N:8]([C:3]4([C:4]([O:6][CH3:7])=[O:5])[CH2:31][CH2:30][CH2:29]4)[C:9]3=[O:26])=[CH:14][CH:13]=2)=[CH:22][CH:21]=1)([O-:25])=[O:24]

参加物

4

反応物 3

HCID 42614147Methyl 1-aminocyclobutane-1-carboxylate hydrochlorideHCID 67306641Methyl 4-(bromomethyl)-4'-nitrobiphenyl-3-carboxylateHCID 131731440(S)-Methyl 3-methyl-2-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate

生成物 1

HCID 67313692Methyl 1-(6-(4-nitrophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylate収率 71%

実験手順

The compound of example 573 was prepared analogous to compound of example 5 by reaction of compound of example 4 with methyl 1-aminocyclobutanecarboxylate hydrochloride.

出典と根拠

ORDレコード
ord-3299c086db7c4247a596710f1681fa26
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

関連ノート

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