化工社化工社 化学情報印刷レポート · 研究参考用
4-(Trifluoromethyl)benzoyl chloride → Methyl 1-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclobutanecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)benzoyl chloride | HCID 67607 | — |
| 反応物 | Methyl 1-(6-(4-aminophenyl)-1-oxoisoindolin-2-yl)cyclobutanecarboxylate | HCID 67314591 | — |
| 反応物 | (S)-Methyl 2-(6-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate | HCID 123625862 | — |
| 生成物 | Methyl 1-(1-oxo-6-(4-(4-(trifluoromethyl)benzamido)phenyl)isoindolin-2-yl)cyclobutanecarboxylate | HCID 53303003 | 83% |
反応手順
The compound of example 579 was prepared analogous to compound of example 97 by reaction of compound of example 574 with 4-trifluoromethyl benzoyl chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748426B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-93c1668ad5e44f11bf06f5d854289b7d |
| 出典メモ | uspto-grants-2014_06 |