HRID404069

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67607

Benzoyl chloride, 4-(trifluoromethyl)-

C8H4ClF3O

结构：COC(=O)C1(N2Cc3ccc(-c4ccc(N)cc4)cc3C2=O)CCC1

HCID67314591

未命名化合物

结构：COC(=O)[C@H](C(C)C)N1Cc2ccc(-c3ccc(NC(=O)c4ccccc4)cc3)cc2C1=O

HCID123625862

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1(N2Cc3ccc(-c4ccc(NC(=O)c5ccc(C(F)(F)F)cc5)cc4)cc3C2=O)CCC1

HCID53303003

未命名化合物

收率 83%

PROCEDURE

实验过程

The compound of example 579 was prepared analogous to compound of example 97 by reaction of compound of example 574 with 4-trifluoromethyl benzoyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-93c1668ad5e44f11bf06f5d854289b7d
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08748426B2
来源说明: uspto-grants-2014_06

反应 SMILES

C(NC1C=CC(C2C=C3C(CN([C@@H](C(C)C)C(OC)=O)C3=O)=CC=2)=CC=1)(=O)C1C=CC=CC=1.[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:49]=[C:48]3[C:44]([CH2:45][N:46]([C:51]4([C:55]([O:57][CH3:58])=[O:56])[CH2:54][CH2:53][CH2:52]4)[C:47]3=[O:50])=[CH:43][CH:42]=2)=[CH:37][CH:36]=1.[F:59][C:60]([F:71])([F:70])[C:61]1[CH:69]=[CH:68][C:64]([C:65](Cl)=[O:66])=[CH:63][CH:62]=1>>[O:50]=[C:47]1[C:48]2[C:44](=[CH:43][CH:42]=[C:41]([C:38]3[CH:37]=[CH:36][C:35]([NH:34][C:65](=[O:66])[C:64]4[CH:68]=[CH:69][C:61]([C:60]([F:59])([F:70])[F:71])=[CH:62][CH:63]=4)=[CH:40][CH:39]=3)[CH:49]=2)[CH2:45][N:46]1[C:51]1([C:55]([O:57][CH3:58])=[O:56])[CH2:52][CH2:53][CH2:54]1