1,2-Dimethyl 4-bromobenzene-1,2-dicarboxylate → (5-Bromo-2-(hydroxymethyl)phenyl)methanol

HRID 404125ノート

反応式

HRID 404125 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:12](OC)=[O:13])[C:5](=[CH:10][CH:11]=1)[C:6](OC)=[O:7].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][OH:7])=[C:4]([CH2:12][OH:13])[CH:3]=1

参加物

4

反応物 2

HCID 113232621,2-Dimethyl 4-bromobenzene-1,2-dicarboxylateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 10798791(5-Bromo-2-(hydroxymethyl)phenyl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

The compound of example 668 (2 g, 7.326 mmol) was taken in dry THF and was added to a slurry of LiAlH4 (1.67 g, 43.95 mmol) in THF cooled to 0° C. The reaction mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with aqueous NaOH solution followed by extraction with ethyl acetate. The solvent was removed by distillation to afford the title compound.

後処理

  1. customThe reaction mixture was quenched with aqueous NaOH solution
  2. extractionfollowed by extraction with ethyl acetate
  3. customThe solvent was removed by distillation

出典と根拠

ORDレコード
ord-d8ab5a7b82304f878bd6cd3318476370
出典データセット
uspto-grants-2014_06
特許番号
US08748426B2

反応ノート

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