2-(1,3-Dimethylbutyl)aniline → HCID 16727057、化合物

HRID 404248

反応式

HRID 404248 の反応式
[CH3:1][CH:2]([C:7]1[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=1[NH2:9])[CH2:3][CH:4]([CH3:6])[CH3:5].[H][H]>O1CCCC1.[Ru]>[CH3:1][CH:2]([CH:7]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:8]1[NH2:9])[CH2:3][CH:4]([CH3:5])[CH3:6]

参加物

5

反応物 2

HCID 115284412-(1,3-Dimethylbutyl)anilineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 16727057HCID 16727057、化合物

試薬・触媒・溶媒 2

HCID 23950Ruthenium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

5 g of Ru/C (5%) are added to a solution comprising 20.0 g (0.113 mol) of 2-(1,3-dimethylbutyl)aniline in 300 ml of tetrahydrofuran, and the mixture is hydrogenated with 100 bar of hydrogen at 120° C. for 24 hours. After cooling to room temperature, the catalyst is filtered off through Celite 545 and the product is concentrated under reduced pressure. This gives 19.1 g (92.4% of theory) of 2-(1,3-dimethylbutyl)cyclohexanamine having a purity of 100% according to HPLC and a log P (pH 2.3) of 4.07.

後処理

  1. filtrationthe catalyst is filtered off through Celite 545
  2. concentrationthe product is concentrated under reduced pressure

出典と根拠

ORDレコード
ord-55aacbb9f58a402fb88f90826dbc2b0e
出典データセット
uspto-grants-2014_06
特許番号
US08748471B2

関連ノート

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