Ethyl Acetate → HCID 19080443、化合物
反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH:12]=[C:13]([CH3:15])[CH3:14].CCOC(C)=O>[Pd]>[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH2:12][CH:13]([CH3:15])[CH3:14]参加物
4
実験手順
To a stirred solution of methyl 4-hydroxy-3-(2-methylprop-1-enyl)benzoate T23.2 (0.320 g, 1.6 mmol) in EtOAc (2.00 mL, 20 mmol) at 23° C. was added palladium on carbon (0.017 g, 0.16 mmol). The reaction was stirred under an atmosphere of hydrogen (0.0031 g, 1.6 mmol) for 16 hours. The reaction mixture was then filtered and concentrated in vacuo to give a clear oil. The residue was purified on silica gel (0-20% EtOAc in hexanes) to yield T23.3 as a colorless oil (0.256 g, 79% yield)
後処理
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated in vacuo
- customto give a clear oil
- customThe residue was purified on silica gel (0-20% EtOAc in hexanes)
出典と根拠
- ORDレコード
- ord-2908acfc8cb54928ad5907df6cfe5ce1
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748462B2
反応ノート
読み込み中…