Phosphorus oxychloride → 1-(3-Chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile
反応式
P(Cl)(Cl)(Cl)=O.[Cl:6][C:7]1[C:8]([N:13]2[CH2:18][CH2:17][C:16](O)([C:19]#[N:20])[CH2:15][CH2:14]2)=[N:9][CH:10]=[CH:11][CH:12]=1>N1C=CC=CC=1>[Cl:6][C:7]1[C:8]([N:13]2[CH2:14][CH:15]=[C:16]([C:19]#[N:20])[CH2:17][CH2:18]2)=[N:9][CH:10]=[CH:11][CH:12]=1参加物
4
実験手順
At 0° C., phosphoryl trichloride (10 g, 68 mmol) was slowly added into a solution of 1-(3-chloropyridin-2-yl)-4-hydroxypiperidine-4-carbonitrile (compound 22) (8 g, 33 mmol) in pyridine. After stirred at RT for 30 minutes, the reaction was washed by a HCl solution, and extracted by ethyl acetate. The organic layer was evaporated to give a crude product, which was purified using column chromatography to give the product.
後処理
- washthe reaction was washed by a HCl solution
- extractionextracted by ethyl acetate
- customThe organic layer was evaporated
出典と根拠
- ORDレコード
- ord-0baa843af5a34f44b8d1d413461c08d2
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748610B2
反応ノート
読み込み中…