Methanol → 1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carboxylic Acid
反応式
[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH:12]=[C:11]([C:14]#N)[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[OH-:16].[Na+].C[OH:19]>C[Si](C)(C)C1C=C(C=CC=1)N>[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH:12]=[C:11]([C:14]([OH:19])=[O:16])[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
A solution of 1-(3-chloropyridin-2-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile (compound 23) in 1 20 ml of NaOH (5 g, 125 mmol) water solution and methanol (20 ml) (V/V=1:1) was heated to reflux, and stirred overnight. The reaction was washed by a HCl solution in an ice bath, and extracted by ethyl acetate. The organic layer was evaporated to give a crude product, which was purified using column chromatography to give the product.
後処理
- temperatureto reflux
- washThe reaction was washed by a HCl solution in an ice bath
- extractionextracted by ethyl acetate
- customThe organic layer was evaporated
出典と根拠
- ORDレコード
- ord-3ae6ca62ab2741cca19f859dc1aa984f
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748610B2
反応ノート
読み込み中…