N-bromobutanimide → 2-Bromo-4-(tert-butyl)aniline
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:19])C(=O)C1>CN(C=O)C.O>[Br:19][C:9]1[CH:10]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:6]=[CH:7][C:8]=1[NH2:11]参加物
5
実験手順
To a solution of 4-tert-butyl-phenylamine (447 g, 3 mol) in DMF (500 mL) was added dropwise NBS (531 g, 3 mol) in DMF (500 mL) at room temperature. Upon completion, the reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated. The crude product was directly used in the next step without further purification.
後処理
- extractionextracted with EtOAc
- washThe organic layer was washed with water, brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
- customThe crude product was directly used in the next step without further purification
出典と根拠
- ORDレコード
- ord-57d8dfbedc054c4db140146be991bfd7
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748612B2
反応ノート
読み込み中…