Isopropanol → Et2AlCN i-PrOH
反応式
C([Al])C.[CH:4]([OH:7])([CH3:6])[CH3:5].[C-:8]#[N:9].[CH2:10]([Al+:12][CH2:13][CH3:14])[CH3:11]>C1COCC1>[Al:12]([C:8]#[N:9])([CH2:13][CH3:14])[CH2:10][CH3:11].[CH3:5][CH:4]([OH:7])[CH3:6]参加物
5
実験手順
The sulfinimine-mediated asymmetric synthesis involves addition of ethylaluminium cyanoisopropoxide generated in situ by addition of isopropanol (i-PrOH) to diethylaluminium cyanide (Et2AlCN) to the compound VIIa. Thus treatment of compound VIIa (1.0 mmol) at −78° C. in THF with 1.5/1.0 equiv of Et2AlCN/i-PrOH gave amino nitrile VIII in good yield (50-70%).
後処理
- customThe sulfinimine-mediated asymmetric synthesis
出典と根拠
- ORDレコード
- ord-868c36ae70b54fae9b68367883f5729d
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08748631B2
反応ノート
読み込み中…