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Hydrochloric Acid → 1-(2-Bromo-4-chlorophenyl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 1-(2-Bromo-4-chlorophenyl)ethanone | HCID 4712644 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-(2-Bromo-4-chlorophenyl)ethanol | HCID 57445073 | — |
反応手順
Solid NaBH4 (354 mg, 9.4 mmol) was added to a 0° C., THF (5 mL) and MeOH (15 mL) solution of 1-(2-bromo-4-chlorophenyl)ethanone (1.8 g, 7.8 mmol). After 30 min 2N aqueous HCl was slowly added, and the resulting mixture was extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08748624B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-de0ade1835f8404786d55c3e197ec22f |
| 出典メモ | uspto-grants-2014_06 |