反应详情

Solid NaBH4 (354 mg, 9.4 mmol) was added to a 0° C., THF (5 mL) and MeOH (15 mL) solution of 1-(2-bromo-4-chlorophenyl)ethanone (1.8 g, 7.8 mmol). After 30 min 2N aqueous HCl was slowly added, and the resulting mixture was extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

1. extractionthe resulting mixture was extracted with EtOAc
2. dry with materialThe combined organic extracts were dried (Na2SO4)
3. concentrationconcentrated
4. custompurified via column chromatography