Acetonitrile → 5-Bromo-N-sec-butylpyrimidin-2-amine

HRID 40563

反応式

HRID 40563 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH:9]([NH2:13])([CH2:11][CH3:12])[CH3:10].C(#N)C>CCOC(C)=O>[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:13][CH:9]([CH2:11][CH3:12])[CH3:10])=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 24874Sec-ButylamineHCID 6066655-Bromo-2-chloropyrimidine

生成物 1

HCID 638737875-Bromo-N-sec-butylpyrimidin-2-amine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
120 °C

実験手順

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine and 3.13 mL (31.0 mmol) sec-butylamin are added to 12 mL ACN. The reaction mixture is stirred at 120° C. for 2 h, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo. C8H12BrN3 (M=230.1 g/mol)

後処理

  1. washwashed with water (2×)
  2. dry with materialphase is dried with MgSO4
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-1d99d59c38ef44dfa691cbcecf9f42e2
出典データセット
uspto-grants-2013_09
特許番号
US08530460B2

関連ノート

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