HCID 58117917、化合物 → HCID 58117573、化合物
反応式
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[C:12](=[O:23])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[C:12](=[O:23])[CH2:11][CH2:10]1参加物
4
実験手順
0.5 g (S)-5-dibenzylamino-1-(4-fluorobenzyl)-piperidin-2-one are placed in 20 ml of methanol and hydrogenated with 0.150 g Pd/C 10% at a pressure of 3 bar and a temperature of 60° C. After 5 hours the catalyst is suction filtered and the filtrate is evaporated to dryness. 0.21 g of the product are obtained as an oil. Analytical HPLC-MS (method A): RT=0.68 min.
後処理
- customa temperature of 60° C
- filtrationsuction filtered
- customthe filtrate is evaporated to dryness
出典と根拠
- ORDレコード
- ord-8de7f9db1ec845e6942aa7f1c4bc4e00
- 出典データセット
- uspto-grants-2014_06
- 特許番号
- US08754073B2
反応ノート
読み込み中…