Diisopropylethylamine → HCID 46913023、化合物

HRID 405942

反応式

HRID 405942 の反応式
[O:1]=[S:2]1[C:10]2[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)=[N:8][C:7]([N:18]3[CH2:23][CH2:22][CH:21]([O:24][C:25]4[CH:33]=[CH:32][C:28]([C:29](O)=[O:30])=[CH:27][CH:26]=4)[CH2:20][CH2:19]3)=[N:6][C:5]=2[CH2:4][CH2:3]1.C([N:37]([CH:40]([CH3:42])[CH3:41])[CH2:38]C)(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.Cl.C1(CN)CC1>CN(C)C=O>[CH:40]1([N:37]([CH3:38])[C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([O:24][CH:21]3[CH2:20][CH2:19][N:18]([C:7]4[N:8]=[C:9]([NH:11][CH:12]5[CH2:17][CH2:16][O:15][CH2:14][CH2:13]5)[C:10]5[S:2](=[O:1])[CH2:3][CH2:4][C:5]=5[N:6]=4)[CH2:23][CH2:22]3)=[CH:33][CH:32]=2)[CH2:41][CH2:42]1

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 81671(Cyclopropylmethyl)ammonium chlorideHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 46912845HCID 46912845、化合物

生成物 1

HCID 46913023HCID 46913023、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

55 mg of Example 184 (see 40.) are placed in 2 ml dimethylformamide, then 81 l diisopropylethylamine and 53.1 mg O-(7-azabenzotriazol-1-yl-)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) are added. After 15 min 13.8 mg cyclopropylmethylamine hydrochloride are added. The reaction mixture is stirred at ambient temperature until there is no further reaction and the product is purified directly by preparative HPLC (method B). 30 mg of Example 242 are obtained as a solid.

後処理

  1. customno further reaction
  2. customthe product is purified directly by preparative HPLC (method B)

出典と根拠

ORDレコード
ord-f5998a79fbcc4c73bfae8095fdc14141
出典データセット
uspto-grants-2014_06
特許番号
US08754073B2

関連ノート

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