1-Piperonylpiperazine → 4-Benzo[1,3]dioxol-5-ylmethyl-piperazine-1-carboxylic acid pyridin-3-ylamide

HRID 40596

反応式

HRID 40596 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1.C1([O:23][C:24](=O)[NH:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)C=CC=CC=1>>[N:28]1[CH:29]=[CH:30][CH:31]=[C:26]([NH:25][C:24]([N:14]2[CH2:13][CH2:12][N:11]([CH2:10][C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)[CH2:16][CH2:15]2)=[O:23])[CH:27]=1

参加物

3

反応物 2

HCID 944261-PiperonylpiperazineHCID 6935890Phenyl pyridin-3-ylcarbamate

生成物 1

HCID 245286484-Benzo[1,3]dioxol-5-ylmethyl-piperazine-1-carboxylic acid pyridin-3-ylamide

実験手順

The title compound was prepared from 1-benzo[1,3]dioxol-5-ylmethyl-piperazine and pyridin-3-yl-carbamic acid phenyl ester in analogy with Example 142. 1H NMR (400 MHz, CDCl3): 8.44-8.43 (m, 1H), 8.19-8.17 (m, 1H), 7.98-7.95 (m, 1H), 7.18-7.16 (m, 1H), 6.83-6.80 (m, 2H), 6.70 (s, 1H), 5.89 (s, 2H), 3.55-3.52 (m, 4H), 3.47 (s, 2H), 2.51-2.48 (m, 4H).

出典と根拠

ORDレコード
ord-2b34314bed5d49e6bd552f22b8d3f2fa
出典データセット
uspto-grants-2013_09
特許番号
US08530476B2

関連ノート

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