Trifluoroacetic acid → HCID 178511743、化合物

HRID 406035ノート

反応式

HRID 406035 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC(=O)[NH:14][C@H:15]1[CH2:18][C@H:17]([O:19][C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[N+:27]([O-:29])=[O:28])[CH2:16]1)(C)(C)C>C(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:26][C:24]1[CH:23]=[CH:22][C:21]([N+:27]([O-:29])=[O:28])=[C:20]([CH:25]=1)[O:19][C@H:17]1[CH2:16][C@H:15]([NH2:14])[CH2:18]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 178454129HCID 178454129、化合物

生成物 1

HCID 178511743HCID 178511743、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

14 ml trifluoroacetic acid were added to a mixture of 2.8 g [trans-3-(5-fluoro-2-nitrophenoxy)-cyclobutyl]-carbamic acid tert-butyl ester in 100 ml methylene chloride at 0° C. The mixture was stirred then for 2 hours at rt and afterwards concentrated. The residue was stirred with diisopropylether and filtered.

後処理

  1. concentrationafterwards concentrated
  2. stirringThe residue was stirred with diisopropylether
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-46df0132cbab41f09e6324caffef544c
出典データセット
uspto-grants-2014_06
特許番号
US08754079B2

反応ノート

読み込み中…