2,4-Difluoronitrobenzene → HCID 58421532、化合物

HRID 406059ノート

反応式

HRID 406059 の反応式
[CH3:1][C:2]([O:5][C:6]([NH:8][C@@H:9]1[C@@H:13]([OH:14])[CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])[CH3:3].[Li+].C[Si]([N-][Si](C)(C)C)(C)C.F[C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[N+:33]([O-:35])=[O:34]>C1COCC1.O>[C:2]([O:5][C:6](=[O:7])[NH:8][C@H:9]1[CH2:10][CH2:11][CH2:12][C@@H:13]1[O:14][C:26]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:27]=1[N+:33]([O-:35])=[O:34])([CH3:1])([CH3:3])[CH3:4]

参加物

6

反応物 3

HCID 679672,4-DifluoronitrobenzeneHCID 2733832Lithium HexamethyldisilazideHCID 10104271tert-Butyl [(1S,2S)-2-hydroxycyclopentyl]carbamate

生成物 1

HCID 58421532HCID 58421532、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
10 °C

実験手順

(1S,2S)-trans-N-boc-2-aminocyclopentanol was dissolved in 50 ml THF and cooled to 10° C. To the reaction mixture were added 32.2 ml LiHMDS 1M in THF. After 1 hour 2.72 ml 2,4-difluoronitrobenzol were added and the mixture was stirred at rt overnight. Then the mixture was poured in water and extracted with ethylacetate. The organic layer was washed with water, dried and concentrated in vacuo.

後処理

  1. extractionextracted with ethylacetate
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-12a2ae7edcfd47aeb5df371811bec19e
出典データセット
uspto-grants-2014_06
特許番号
US08754079B2

反応ノート

読み込み中…